Research

The Neubie® is a breakthrough neuromuscular electrical stimulation (NMES) device.

Image link

The Neubie device is FDA-cleared for indications such as maintaining and increasing range of motion, increasing local blood flow, and neuromuscular re-education. Since neuromuscular re-education is directly related to muscle recruitment, the Neubie is hypothesized to have a potential effect on muscle strength and hypertrophy.

The Muscular Response to the Neubie Device VS. Traditional Resistance Exercise

In this study, we compared acute changes in muscle thickness, isometric torque, and soreness before and up to 48 hours following no resistance training with the Neubie vs. traditional high load resistance training.

The Study

  • 34 Participants, Ages 18-35
  • Those that have regularly engaged in upper body resistance training for at least 6 months

Participants Underwent

  • 1 familiarization session
  • 1 resistance training session
  • 2 measurement sessions (24 and 48 hours after training)

Neubie Group

  • One arm completed no load resistance training with the Neubie
  • 4 sets of 20
    Power of 7/10 (subjective)

Image link

Traditional Resistance Training (TRAD) Group

  • One arm completed no load resistance training with the Neubie
  • 4 sets of 20
    Power of 7/10 (subjective)

Training Visit

Training Visit

Results

Muscle Thickness

Neubie and traditional training both led to significantly increased muscle thickness compared to pre-training. 

Pre-training
3.7
cm
24 hours after training
0
cm
Neubie
0
cm
Traditional Training

Soreness

Neubie resulted in significantly greater levels of delayed onset muscle soreness compared to traditional training.

Pre-training
0.3
/ 10
24 hours after training
0
/ 10
Neubie
0
/ 10
Traditional Training

Conclusion

Short-term training with the Neubie results in similar acute responses as traditional high load training in areas of increased muscle thickness, fatigue and soreness, but with lower perceived exertion. These acute effects may indicate the same amount of muscle growth or strength improvements can be achieved without the additional strain on joints, making it safe, effective, and viable alternative to traditional training.

Neubie

Clinical Research

We are currently working on several formal scientific research projects, including several registered clinical trials. Here is an overview of our studies in progress, and we and are excited to share those results with you as they come available.

  • This field is for validation purposes and should be left unchanged.

Clinical Outcomes: A Multi-Center Study Looking at how NeuFit Impacts Post-Surgical Outcomes

We are working with Orthopedic One, of Columbus, Ohio, and Arrowhead Orthopedics of Southern California, to compare the outcomes for patients using the standard-of-care physical therapy protocols to recover from orthopedic surgery and patients using NeuFit.

Underlying Mechanisms: How the Neubie Impacts the Cellular Processes Related to Muscle Hypertrophy

We are working with the Muscle Physiology Laboratory at the University of South Florida (U.S.F.), led by Dr. Sam Buckner, Ph.D., to look at what happens at a biochemical and structural level as the body recovers from a NEUBIE session. One of the current hypotheses being evaluated is that the NEUBIE can be used to create muscle hypertrophy without external load.

Measuring the Autonomic Response to NeuFit Sessions

In partnership with BioStrap Labs, we are measuring the impact of the Neubie on various biomarkers, like heart rate variability (HRV), sleep quality, and blood flow. Early data is showing that the NEUBIE does increase HRV, which is a powerful indicator of parasympathetic nervous system function and has profound effects on overall health, recovery, and the ability to handle physical, psychological, and emotional stress.

Studying the Effect of NeuFit on Neurological Populations

In partnership with a couple of hospital systems, we are evaluating the ability of the Neubie to restore function in patients who have had a stroke or who have M.S. We are also working on a multi-center study to measure the impact of the Neubie on patients with neuropathy. 

Published Studies

The Muscular Response to the Neubie Device VS. Traditional Resistance Exercise

In this study, we compared acute changes in muscle thickness, isometric torque, and soreness before and up to 48 hours following no resistance training with the Neubie vs. traditional high load resistance training.

Location: University of South Florida Muscle Laboratory | Director: Professor of Exercise Science, Dr. Samuel Buckner, PhD

Investigating the therapeutic effects of Neubie Direct Current Neuromuscular Electrical Stimulation treatment on pain, range of motion, and biometrics measured by the Biostrap wrist-worn photoplethysmography (PPG) device

Longoria, Kevin, Martin, Kerry, Gielen, Willem, & Von Leden, Ramona. (2021).

The Muscular Response to the Neubie Device VS. Traditional Resistance Exercise

E. Vasenina, R. Kataoka, W.B. Hammert, A.H. Ibrahim, S.L. Buckner (2022)

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  18. Maffiuletti NA, Gondin J, Place N, Stevens-Lapsley J, Vivodtzev I, Minetto MA. Clinical Use of Neuromuscular Electrical Stimulation for Neuromuscular Rehabilitation: What Are We Overlooking? Arch Phys Med Rehabil. 2018 Apr;99(4):806-812. doi: 10.1016/j.apmr.2017.10.028. Epub 2017 Dec 9. PMID: 29233625
  19. Knutson JS, Fu MJ, Sheffler LR, Chae J. Neuromuscular Electrical Stimulation for Motor Restoration in Hemiplegia. Phys Med Rehabil Clin N Am. 2015 Nov;26(4):729-45. doi: 10.1016/j.pmr.2015.06.002. Epub 2015 Aug 14. PMID: 26522909; PMCID: PMC4630679.
  20. Chandrasekaran S, Davis J, Bersch I, Goldberg G, Gorgey AS. Electrical stimulation and denervated muscles after spinal cord injury. Neural Regen Res. 2020 Aug;15(8):1397-1407. doi: 10.4103/1673-5374.274326. PMID: 31997798; PMCID: PMC7059583.
  21. Carnaby GD, LaGorio L, Silliman S, Crary M. Exercise-based swallowing intervention (McNeill Dysphagia Therapy) with adjunctive NMES to treat dysphagia post-stroke: A double-blind placebo-controlled trial. J Oral Rehabil. 2020 Apr;47(4):501-510. doi: 10.1111/joor.12928. Epub 2020 Jan 19. PMID: 31880338; PMCID: PMC7067660.
  22. Stein RB , Chong SL, James KB, et al. . Electrical stimulation for therapy and mobility after spinal cord injury. Prog Brain Res.2002 ;137:27–34.
  23. Belanger M , Stein RB, Wheeler GD, et al. . Electrical stimulation: can it increase muscle strength and reverse osteopenia in spinal cord injured individuals? Arch Phys Med Rehabil.2000 ;81:1090–1098.
  24. Wakahara T, Shiraogawa A. Effects of neuromuscular electrical stimulation training on muscle size in collegiate track and field athletes. PLoS One. 2019 Nov 13;14(11):e0224881. doi: 10.1371/journal.pone.0224881. PMID: 31721812; PMCID: PMC6853328.
  25. Gondin J, Cozzone PJ, Bendahan D. Is high-frequency neuromuscular electrical stimulation a suitable tool for muscle performance improvement in both healthy humans and athletes? Eur J Appl Physiol. 2011 Oct;111(10):2473-87. doi: 10.1007/s00421-011-2101-2. Epub 2011 Sep 10. PMID: 21909714.
  26. Gondin J, Brocca L, Bellinzona E, D'Antona G, Maffiuletti NA, Miotti D, Pellegrino MA, Bottinelli R. Neuromuscular electrical stimulation training induces atypical adaptations of the human skeletal muscle phenotype: a functional and proteomic analysis. J Appl Physiol (1985). 2011 Feb;110(2):433-50. doi: 10.1152/japplphysiol.00914.2010. Epub 2010 Dec 2. PMID: 21127206.
  27. Jandova T, Narici MV, Steffl M, Bondi D, D'Amico M, Pavlu D, Verratti V, Fulle S, Pietrangelo T. Muscle Hypertrophy and Architectural Changes in Response to Eight-Week Neuromuscular Electrical Stimulation Training in Healthy Older People. Life (Basel). 2020 Sep 8;10(9):184. doi: 10.3390/life10090184. PMID: 32911678; PMCID: PMC7554879.
  28. Mancinelli R, Toniolo L, Di Filippo ES, Doria C, Marrone M, Maroni CR, Verratti V, Bondi D, Maccatrozzo L, Pietrangelo T, Fulle S. Neuromuscular Electrical Stimulation Induces Skeletal Muscle Fiber Remodeling and Specific Gene Expression Profile in Healthy Elderly. Front Physiol. 2019 Nov 27;10:1459. doi: 10.3389/fphys.2019.01459. PMID: 31827446; PMCID: PMC6890722.
  29. Di Filippo ES, Mancinelli R, Marrone M, Doria C, Verratti V, Toniolo L, Dantas JL, Fulle S, Pietrangelo T. Neuromuscular electrical stimulation improves skeletal muscle regeneration through satellite cell fusion with myofibers in healthy elderly subjects. J Appl Physiol (1985). 2017 Sep 1;123(3):501-512. doi: 10.1152/japplphysiol.00855.2016. Epub 2017 Jun 1. PMID: 28572500.
  30. Pigarev IN, Pigareva ML. Therapeutic Effects of Electrical Stimulation: Interpretations and Predictions Based on the Visceral Theory of Sleep. Front Neurosci. 2018 Feb 12;12:65. doi: 10.3389/fnins.2018.00065. PMID: 29483861; PMCID: PMC5816067.
  31. Chen, Y., Ye, L., Guan, L., Fan, P., Liu, R., Liu, H., Chen, J., Zhu, Y., Wei, X., Liu, Y., Bai, H., Physiological electric field works via the VEGF receptor to stimulate neovessel formation of vascular endothelial cells in a 3D environment. Biol Open, 7(9), 2018. 
  32. Hu, W.W., Chen, T.C., Tsao, C.W., Cheng, Y.C., The effects of substrate-mediated electrical stimulation on the promotion of osteogenic differentiation and its optimization. J Biomed Mater Res B Appl Biomater, 2018. 
  33. Rouabhia, M., Park, H., Meng, S., Derbali, H., Zhang, Z. Electrical stimulation promotes wound healing by enhancing dermal fibroblast activity and promoting myofibroblast transdifferentiation. PLoS One. 8(8), 2013.
  34. Borgens R.B., Vanable J.W., Jaffe L.F., Bioelectricity and regeneration. I. Initiation of frog limb regeneration by minute currents. J Exp Zool. 200(3), 1977. 
  35. Leppik L.P., Froemel D., Slavici A., Ovadia Z.N., Hudak L., Henrich D., Marzi I., Barker J.H., Effects of electrical stimulation on rat limb regeneration, a new look at an old model. Sci Rep. 5, 2015.
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  50. Stackhouse S.K., Taylor C.M., Eckenrode B.J., Stuck E., Davey H., Effects of Noxious Electrical Stimulation and Eccentric Exercise on Pain Sensitivity in Asymptomatic Individuals. PM R, 8(5), 2016.
  51. Fujii-Abe K, Umino M, Fukayama H, Kawahara H., Enhancement of Analgesic Effect by Combination of Non-Noxious Stimulation and Noxious Stimulation in Humans. Pain Pract, 16(2), 2016. 
  52. Eckenrode BJ, Stackhouse SK., Improved Pressure Pain Thresholds and Function Following Noxious Electrical Stimulation on a Runner with Chronic Achilles Tendinopathy: a Case Report. Int J Sports Phys Ther, 10(3), 2015. 
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  56. Paillard T. Combined application of neuromuscular electrical stimulation and voluntary muscular contractions. Sports Med. 2008;38(2):161-77. doi: 10.2165/00007256-200838020-00005. PMID: 18201117

Join the Movement #NeuFit

The Muscular Response to the Neubie Device VS. Traditional Resistance Exercise

The Neubie device is FDA-cleared for indications such as maintaining and increasing range of motion, increasing local blood flow, and neuromuscular re-education. Since neuromuscular re-education is directly related to muscle recruitment, the Neubie is hypothesized to have a potential effect on muscle strength and hypertrophy.

In this study, we compared acute changes in muscle thickness, isometric torque, and soreness before and up to 48 hours following no resistance training with the Neubie vs. traditional high load resistance training.

The Study

  • 34 Participants, Ages 18-35
  • Those that have regularly engaged in upper body resistance training for at least 6 months

Participants Underwent

  • 1 familiarization session
  • 1 resistance training session
  • 2 measurement sessions (24 and 48 hours after training)

Neubie Group

  • One arm completed no load resistance training with the Neubie
  • 4 sets of 20
    Power of 7/10 (subjective)

Image link

Traditional Resistance Training (TRAD) Group

  • One arm completed no load resistance training with the Neubie
  • 4 sets of 20
    Power of 7/10 (subjective)

Training Visit

Training Visit

Results

Muscle Thickness

Neubie and traditional training both led to significantly increased muscle thickness compared to pre-training. 

Pre-training
3.7
cm
24 hours after training
0
cm
Neubie
0
cm
Traditional Training

Soreness

Neubie resulted in significantly greater levels of delayed onset muscle soreness compared to traditional training.

Pre-training
0.3
/ 10
24 hours after training
0
/ 10
Neubie
0
/ 10
Traditional Training

Conclusion

Short-term training with the Neubie results in similar acute responses as traditional high load training in areas of increased muscle thickness, fatigue and soreness, but with lower perceived exertion. These acute effects may indicate the same amount of muscle growth or strength improvements can be achieved without the additional strain on joints, making it safe, effective, and viable alternative to traditional training.